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Securin Is a Target of the UV Response Pathway in Mammalian Cells

Opened Access Securin Is a Target of the UV Response Pathway in Mammalian Cells

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Autor: Romero Portillo, Francisco
Gil-Bernabé, Ana M.
Sáez, Carmen
Pintor Toro, José Antonio
Tortolero García, María Dolores
Departamento: Universidad de Sevilla. Departamento de Microbiología
Universidad de Sevilla. Departamento de Anatomía Patológica
Fecha: 2004
Publicado en: Molecular and Cellular Biology, 24 (7), 2720-2733.
Tipo de documento: Artículo
Resumen: All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to a protease called Separase to inhibit sister chromatid separation until the onset of anaphase. At the metaphase-to-anaphase transition, Securin is degraded by the anaphase-promoting complex or cyclosome, and Separase contributes to the release of cohesins from the chromosome, allowing for the segregation of sister chromatids to opposite spindle poles. Here we provide evidence that human Securin (hSecurin) has a novel role in cell cycle arrest after exposure to UV light or ionizing radiation. In fact, irradiation downregulated the level of hSecurin protein, accelerating its degradation via the proteasome and reducing hSecurin mRNA translation, but the presence of hSecurin is necessary for cell proliferation arrest following UV treatment. Moreover, an alteration of UV-...
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Cita: Romero Portillo, F., Gil-Bernabé, A.M., Sáez, C., Pintor Toro, J.A. y Tortolero García, M.D. (2004). Securin Is a Target of the UV Response Pathway in Mammalian Cells. Molecular and Cellular Biology, 24 (7), 2720-2733.
Tamaño: 650.9Kb
Formato: PDF

URI: https://hdl.handle.net/11441/70790

DOI: 10.1128/MCB.24.7.2720-2733.2004

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