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Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Opened Access Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

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Autor: Vries, Ronald P. de
Aguilar Osorio, Guillermo
Riley, Robert
Wiebenga, Ad
Cánovas López, David
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2017
Publicado en: Genome Biology, 18 (28), 1-45.
Tipo de documento: Artículo
Resumen: Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic aci...
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Cita: Vries, R.P.d., Aguilar Osorio, G., Riley, R., Wiebenga, A. y Cánovas López, D. (2017). Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biology, 18 (28), 1-45.
Tamaño: 8.940Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70557

DOI: 10.1186/s13059-017-1151-0

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