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Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus

Opened Access Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus

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Autor: Visiedo, Francisco
Santos Rosendo, Celeste
Mateos Bernal, Rosa M.
Gil Sánchez, María del Mar
Aguilar Diosdado, Manuel
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2017
Publicado en: Oxidative Medicine and Cellular Longevity, 5629341, 1-10.
Tipo de documento: Artículo
Resumen: Dysregulation of NO production is implicated in pregnancy-related diseases, including gestational diabetes mellitus (GDM). The role of NO and its placental targets in GDM pregnancies has yet to be determined. S-Nitrosylation is the NO-derived posttranslational protein modification that can modulate biological functions by forming NO-derived complexes with longer half-life, termed S-nitrosothiol (SNO). Our aim was to examine the presence of endogenous S-nitrosylated proteins in cysteine residues in relation to antioxidant defense, apoptosis, and cellular signal transduction in placental tissue from control (n = 8) and GDM (n = 8) pregnancies. S-Nitrosylation was measured using the biotin-switch assay, while the expression and protein activity were assessed by immunoblotting and colorimetric methods, respectively. Results indicated that catalase and peroxiredoxin nitrosylation levels were greater in GDM placentas, and that was accompanied by reduced catalase activity. S-Nitrosylation of...
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Cita: Visiedo, F., Santos Rosendo, ., Mateos Bernal, .M., Gil Sánchez, M.d.M. y Aguilar Diosdado, M. (2017). Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity, 5629341, 1-10.
Tamaño: 469.8Kb
Formato: PDF

URI: https://hdl.handle.net/11441/70545

DOI: 10.1155/2017/5629341

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