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The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment

Opened Access The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment

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Autor: García Heredia, José Manuel
Carnero Moya, Amancio
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2017
Publicado en: Oncotarget, 8 (58), 98580-98597.
Tipo de documento: Artículo
Resumen: Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged cells and initiating healing and regenerative processes. Chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a cargo protein that transports membrane proteins from the endoplasmic reticulum. Therefore, its overexpression may be linked to an excess of membrane proteins that may be recognized as an unwanted signal, triggering local inflammation. Therefore, we analyzed whether its overexpression is related to an inflammatory phenotype. In this work, we found a correlation between MAP17 expression and inflammatory phenotype in tumors and in other inflammatory diseases such as Crohn's disease, Barrett's esophagus, COPD or psoriasis. MAP17 expression correlated also with the markers of inflammation HLAs, BBS10, HERC2, ADNP and PYCARD. Furthermore, we found that MAP17 expression directly regulates NFA...
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Cita: García Heredia, J.M. y Carnero Moya, A. (2017). The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment. Oncotarget, 8 (58), 98580-98597.
Tamaño: 4.183Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70524

DOI: 10.18632/oncotarget.21651

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