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Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

Opened Access Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

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Autor: Cruz Gallardo, Isabel
Díaz Moreno, Irene
Díaz Quintana, Antonio Jesús
Velázquez Campoy, Adrián
Curd, Rachel D.
Rangachari, Caveri
Bridsall, Berry
Ramos, Andrés
Holder, Anthony A.
Rosa Acosta, Miguel Ángel de la
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2013
Publicado en: Journal of Biological Chemistry, 288 (29), 20896-20907.
Tipo de documento: Artículo
Resumen: Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugs
Cita: Cruz Gallardo, I., Díaz Moreno, I., Díaz Quintana, A.J., Velázquez Campoy, A., Curd, R.D., Rangachari, C.,...,Rosa Acosta, M.Á.d.l. (2013). Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin. Journal of Biological Chemistry, 288 (29), 20896-20907.
Tamaño: 3.773Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70218

DOI: 10.1074/jbc.M113.460162

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