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Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases

dc.creatorMoreno Clavijo, Elenaes
dc.creatorCarmona Asenjo, Ana Teresaes
dc.creatorMoreno Vargas, Antonio Josées
dc.creatorÁlvarez González, Eleuterioes
dc.creatorRobina Ramírez, Inmaculadaes
dc.date.accessioned2018-02-09T15:46:29Z
dc.date.available2018-02-09T15:46:29Z
dc.date.issued2010
dc.identifier.citationMoreno Clavijo, E., Carmona Asenjo, A.T., Moreno Vargas, A.J., Álvarez, E. y Robina Ramírez, I. (2010). Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases. Synlett, 9, 1367-1370.
dc.identifier.issn0936-5214es
dc.identifier.issn1437-2096 (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/70186
dc.description.abstractThe synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of aza-C-glycosides having a biimino (-NH-NH-) moiety. The key step of the synthesis is the introduction of the hydrazine moiety by reductive hydrazination of a 1-deoxy-ketohexose with tert-butyl carbazate. Their glycosidase inhibitory properties are also reported.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación of Spain CTQ2008-01565/BQUes
dc.description.sponsorshipJunta de Andalucía FQM-345 and P07-FQM-03056es
dc.formatapplication/pdfes
dc.language.isoenges
dc.relation.ispartofSynlett, 9, 1367-1370.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAzasugarses
dc.subjectGlycosidaseses
dc.subjectFucosidase inhibitorses
dc.subjectAza-fagomineses
dc.subjectC-glycosideses
dc.titleSynthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidaseses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.publisherversionhttp://dx.doi.org/10.1055/s-0029-1219906es
dc.identifier.doi10.1055/s-0029-1219906es
idus.format.extent4es
dc.journaltitleSynlettes
dc.publication.issue9es
dc.publication.initialPage1367es
dc.publication.endPage1370es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). España
dc.contributor.funderJunta de Andalucía

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