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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

 

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Opened Access The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
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Author: Lafuente Barquero, Juan
Luke Glaser, Sarah
Graf, Marco
Silva, Sonia
Gómez González, Belén
Aguilera López, Andrés
Department: Universidad de Sevilla. Departamento de Genética
Date: 2017
Published in: PLoS Genetics, 13 (12), 1-25.
Document type: Article
Abstract: RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and compromised genomic integrity. W...
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Cite: Lafuente Barquero, J., Luke Glaser, ., Graf, M., Silva, S., Gómez González, B. y Aguilera López, A. (2017). The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genetics, 13 (12), 1-25.
Size: 6.249Mb
Format: PDF

URI: https://hdl.handle.net/11441/70178

DOI: 10.1371/journal.pgen.1007136

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This work is under a Creative Commons License: 
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