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TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo

 

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Opened Access TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
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Author: Gómez Herreros, Fernando
Romero Granados, Rocío
Zeng, Zhihong
Álvarez Quilón, Alejandro
Quintero Ruiz, María Cristina
Ju, Limei
Umans, Lieve
Vemeire, Liesbeth
Huylebroeck, Danny
Caldecott, Keith W.
Cortés Ledesma, Felipe
Date: 2013
Published in: Plos Genetics, 9 (3), e1003226-.
Document type: Article
Abstract: Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy of TOP2 poisons, but is also implica...
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Cite: Gómez Herreros, F., Romero Granados, R., Zeng, Z., Álvarez Quilón, A., Quintero Ruiz, M.C., Ju, L.,...,Cortés Ledesma, F. (2013). TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo. Plos Genetics, 9 (3), e1003226-.
Size: 2.876Mb
Format: PDF

URI: https://hdl.handle.net/11441/70142

DOI: 10.1371/journal.pgen.1003226

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