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Beyond toxicity: A regulatory role for mitochondrial cyanide


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Author: García Domínguez, Irene
Gotor Martínez, Cecilia
Romero González, Luis Carlos
Date: 2014
Published in: Plant signaling & behavior, 9
Document type: Article
Abstract: In non-cyanogenic plants, cyanide is a co-product of ethylene and camalexin biosynthesis. To maintain cyanide at non-toxic levels, Arabidopsis plants express the mitochondrial β-cyanoalanine synthase CYS-C1. CYS-C1 knockout leads to an increased level of cyanide in the roots and leaves and a severe defect in root hair morphogenesis, suggesting that cyanide acts as a signaling factor in root development. During compatible and incompatible plant-bacteria interactions, cyanide accumulation and CYS-C1 gene expression are negatively correlated. Moreover, CYS-C1 mutation increases both plant tolerance to biotrophic pathogens and their susceptibility to necrotrophic fungi, indicating that cyanide could stimulate the salicylic acid-dependent signaling pathway of the plant immune system. We hypothesize that CYS-C1 is essential for maintaining non-toxic concentrations of cyanide in the mitochondria to facilitate cyanide’s role in signaling.
Cite: García Domínguez, I., Gotor Martínez, C. y Romero González, L.C. (2014). Beyond toxicity: A regulatory role for mitochondrial cyanide. Plant signaling & behavior, 9
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DOI: 10.4161/psb.27612

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