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Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability

Opened Access Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability

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Autor: Muñoz-Barrera, Marta
Monje-Casas, Fernándo
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2014
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 111 (38), E3996-E4005.
Tipo de documento: Artículo
Resumen: Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct erroneous kinetochore-microtubule attachments and gives rise to aneuploidy. Interestingly, increased Aurora B activity also leads to problems with chromosome segregation, and overexpression of this kinase has been observed in various types of cancer. However, little is known about the mechanisms by which an increase in Aurora B kinase activity can impair mitotic progression and cell viability. Here, using a yeast model, we demonstrate that increased Aurora B activity as a result of the overexpression of the Aurora B and inner centromere protein homologs triggers defects in chromosome segregation by promoting the continuous disruption of chromosome-microtubule attachments even when sister chromatids are correctly bioriented. This disruption leads to a constitutive activation of the spindle-assembly checkpoint, which therefore cause...
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Cita: Muñoz-Barrera, M. y Monje-Casas, F. (2014). Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability. Proceedings of the National Academy of Sciences of the United States of America, 111 (38), E3996-E4005.
Tamaño: 1.716Mb
Formato: PDF

URI: https://hdl.handle.net/11441/69257

DOI: 10.1073/pnas.1408017111

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