Repositorio de producción científica de la Universidad de Sevilla

Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability

Opened Access Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Boccardi, Elena
Philippart, Anahí
Juhasz-Bortuzzo, Judith A.
Beltrán, A.M.
Novajra, Giorgia
Vitale-Brovarone, Chiara
Spiecker, Erdmann
Boccaccini, Aldo R.
Departamento: Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte
Fecha: 2015
Publicado en: Frontiers in Bioengineering and Biotechnology, 3
Tipo de documento: Artículo
Resumen: The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle...
[Ver más]
Cita: Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J.A., Beltrán, A.M., Novajra, G., Vitale-Brovarone, C.,...,Boccaccini, A.R. (2015). Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (McM-41) for enhancing drug delivery capability. Frontiers in Bioengineering and Biotechnology, 3
Tamaño: 11.79Mb
Formato: PDF

URI: http://hdl.handle.net/11441/68327

DOI: 10.3389/fbioe.2015.00177

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones