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Application of Phosphine-Phosphite Ligands in the Iridium Catalyzed Enantioselective Hydrogenation of 2-Methylquinoline

 

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dc.creator Rubio Moreno, Miguel es
dc.creator Pizzano Mancera, Antonio es
dc.date.accessioned 2017-12-29T09:07:01Z
dc.date.available 2017-12-29T09:07:01Z
dc.date.issued 2010-10-29
dc.identifier.issn 1420-3049 (impreso) es
dc.identifier.uri http://hdl.handle.net/11441/68070
dc.description.abstract The hydrogenation of 2-methylquinoline with Ir catalysts based on chiral phosphine-phosphites has been investigated. It has been observed that the reaction is very sensitive to the nature of the ligand. Optimization of the catalyst, allowed by the highly modular structure of these phosphine-phosphites, has improved the enantioselectivity of the reaction up to 73% ee. The influence of additives in this reaction has also been investigated. Contrary to the beneficial influence observed in related catalytic systems, iodine has a deleterious effect in the present case. Otherwise, aryl phosphoric acids produce a positive impact on catalyst activity without a decrease on enantioselectivity. es
dc.description.sponsorship Ministerio de Ciencia e Innovación CTQ2009-11867, CSD2007- 00006 es
dc.description.sponsorship Junta de Andalucía, 2008/ FQM-3830 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Multidisciplinary Digital Publishing Institute es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Asymmetric hydrogenation es
dc.subject Chiral ligands es
dc.subject Phosphites es
dc.subject Iridium es
dc.subject Quinolines es
dc.title Application of Phosphine-Phosphite Ligands in the Iridium Catalyzed Enantioselective Hydrogenation of 2-Methylquinoline es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Química Inorgánica es
dc.relation.projectID CTQ2009-11867 es
dc.relation.projectID CSD2007- 00006 es
dc.relation.projectID 2008/ FQM-3830 es
dc.relation.publisherversion http://dx.doi.org/10.3390/molecules15117732 es
dc.identifier.doi 10.3390/molecules15117732 es
idus.format.extent 10 p. es
dc.journaltitle Molecules es
dc.publication.volumen 15 es
dc.publication.issue 11 es
dc.publication.initialPage 7732 es
dc.publication.endPage 7741 es
dc.identifier.sisius 6538064 es
dc.contributor.funder Ministerio de Ciencia e Innovación (MICIN). España
dc.contributor.funder Junta de Andalucía
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