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Simulating FAS-induced apoptosis by using P systems

Opened Access Simulating FAS-induced apoptosis by using P systems
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Autor: Cheruku, Smitha
Paun, Andrei
Romero Campero, Francisco José
Pérez Jiménez, Mario de Jesús
Ibarra, Óscar H.
Departamento: Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial
Fecha: 2007
Publicado en: Progress in Natural Science, 17 (4), 424-431.
Tipo de documento: Artículo
Resumen: In contrast to differential equations, P systems are an unconven- tional model of computation which takes into consideration the discrete character of the quantity of components and the inherent randomness that exists in biological phenomena. The key feature of P systems is their compartmentalised structure which represents the heterogeneity of the structural organisation of the cells, and where one can take into account the role played by membranes in the functioning of the system, for example signalling at the cell surface [13], selective uptake of sub- stances from the media [14], diffusion across different compartments [15], etc. We show here that P systems can be a reliable tool for Systems Biology and could even outperform in some cases the current simu- lation techniques based on differential equations. We will also use a strategy based on the well known Gillespie algorithm [4] but running on more than one compartment called Multi-compartmental Gillespie Algorith...
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Cita: Cheruku, S., Paun, A., Romero Campero, F.J., Pérez Jiménez, M.d.J. y Ibarra, Ó.H. (2007). Simulating FAS-induced apoptosis by using P systems. Progress in Natural Science, 17 (4), 424-431.
Tamaño: 312.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/67977

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