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The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii

 

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dc.creator Pérez Pérez, María Esther es
dc.creator Couso Liáñez, Inmaculada Concepción es
dc.creator Crespo, José Luis es
dc.date.accessioned 2017-12-20T16:28:19Z
dc.date.available 2017-12-20T16:28:19Z
dc.date.issued 2017
dc.identifier.citation Pérez Pérez, M.E., Couso Liáñez, I.C. y Crespo, J.L. (2017). The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii. Biomolecules, 7 (3), 54-54.
dc.identifier.issn 2218-273X es
dc.identifier.uri http://hdl.handle.net/11441/67882
dc.description.abstract Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). While the structure and functions of TORC1 are highly conserved in all eukaryotes, including algae and plants, TORC2 core proteins seem to be missing in photosynthetic organisms. TORC1 controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. Recent studies identified rapamycin-sensitive TORC1 signaling regulating cell growth, autophagy, lipid metabolism, and central metabolic pathways in the model unicellular green alga <i>Chlamydomonas reinhardtii</i>. The central role that microalgae play in global biomass production, together with the high biotechnological potential of these organisms in biofuel production, has drawn attention to the study of proteins that regulate cell growth such as the TOR kinase. In this review we discuss the recent progress on TOR signaling in algae. es
dc.description.sponsorship España, MINECO BFU2015-68216-P es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher MDPI es
dc.relation.ispartof Biomolecules, 7 (3), 54-54.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject target of rapamycin (TOR) es
dc.subject rapamycin es
dc.subject FKBP12 es
dc.subject Chlamydomonas es
dc.subject algae es
dc.subject autophagy es
dc.subject lipid metabolism es
dc.title The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular es
dc.relation.projectID BFU2015-68216-P es
dc.relation.publisherversion https://doi.org/10.3390/biom7030054 es
dc.identifier.doi 10.3390/biom7030054 es
idus.format.extent 1 p. es
dc.journaltitle Biomolecules es
dc.publication.volumen 7 es
dc.publication.issue 3 es
dc.publication.initialPage 54 es
dc.publication.endPage 54 es
dc.contributor.funder Ministerio de Economía y Competitividad (MINECO). España
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