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Aproximación neuropatológica a la fisiopatología de la enfermedad de Alzheimer

Opened Access Aproximación neuropatológica a la fisiopatología de la enfermedad de Alzheimer
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Autor: Serrano Pozo, Alberto
Director: Calderón Sandubete, Enrique José
Hyman, Bradley T.
Gil Néciga, Eulogio
Departamento: Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública
Fecha: 2013-04-22
Tipo de documento: Tesis Doctoral
Resumen: Introduction: Amyloid plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of Alzheimer disease (AD), but other important lesions are cerebral amyloid angiopathy, glial responses (reactive astrocytes and activated microglia), and a progressive loss of synapses and neurons. The most widely accepted hypothesis on the pathophysiology of AD, termed ¿amyloid cascade hypothesis¿, postulates that amyloid deposition triggers a cascade of adverse events that include, among others, glial responses, tau hyperphosphorylation and aggregation in NFTs, and massive synaptic and neuron losses, that ultimately lead to dementia. Rationale/hypothesis/aims: We hypothesized that as the disease advances the amyloid cascade becomes progressively independent of its initiator, the Aß peptide, so that removing the plaques from the brain in the symptomatic phase would be insufficient to arrest or rescue Aß downstream effects. We aimed at 1) understanding the progression of the different ...
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Cita: Serrano Pozo, A. (2013). Aproximación neuropatológica a la fisiopatología de la enfermedad de Alzheimer. (Tesis Doctoral Inédita). Universidad de Sevilla, Sevilla.
Tamaño: 6.586Mb
Formato: PDF

URI: http://hdl.handle.net/11441/67746

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