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Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia

Opened Access Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia

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Autor: Leiva Mendoza, Andrea
Fuenzalida, Bárbara
Westermeier, Francisco
Toledo, Fernando
Salomón Gallo, Carlos
Gutiérrez, Jaime
Sanhueza, Carlos
Sobrevia Luarte, Luis
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2015
Publicado en: Oxidative Medicine and Cellular Longevity, 5346327, 1-10.
Tipo de documento: Artículo
Resumen: Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological hypercholesterolemia (MSPH). This condition results in endothelial dysfunction and atherosclerosis in the fetal and placental vasculature. The fetal and placental endothelial dysfunction is related to alterations in the L-arginine/nitric oxide (NO) pathway and the arginase/urea pathway and results in reduced NO production. The level of tetrahydrobiopterin (BH4), a cofactor for endothelial NO synthase (eNOS), is reduced in nonpregnant women who have hypercholesterolemia, which favors the generation of the superoxide anion rather than NO (from eNOS), causing endothelial dysfunction. However, it is unknown whether MSPH is associated with changes in the level or metabolism of BH4; as a result, eNOS function is not well understood. This review summarize...
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Cita: Leiva, A., Fuenzalida, B., Westermeier, ., Toledo, F., Salomón Gallo, C., Gutiérrez, J.,...,Sobrevia Luarte, L. (2015). Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia. Oxidative Medicine and Cellular Longevity, 5346327, 1-10.
Tamaño: 664.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/67631

DOI: 10.1155/2016/5346327

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