Repositorio de producción científica de la Universidad de Sevilla

Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.

 

Advanced Search
 
Opened Access Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.
Cites
Show item statistics
Icon
Export to
Author: Berrougui, Hicham
López Lázaro, Miguel
Martín Cordero, Carmen
Mamouchi, Mohamed
Ettaib, Abdelkader
Herrera González, María Dolores
Department: Universidad de Sevilla. Departamento de Farmacología
Date: 2005
Published in: Journal of Natural Remedies, 5 (1), 41-45.
Document type: Article
Abstract: To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by spectroscopic-Mass and NMR methods. The cytotoxicity of the methanolic extract and both alkaloids has been investigated in the three human cancer cell lines UACC-62 (melanoma), TK-10 (renal) and MCF-7 (breast) and then compared to the positive control effect of the etoposide. Results and conclusion: The methanolic extract and both alkaloids have inhibited the growth of these three cancer cell-lines and we have discussed possible mechanisms involved in their cytotoxicity.
Cite: Berrougui, H., López Lázaro, M., Martín Cordero, C., Mamouchi, M., Ettaib, A. y Herrera González, M.D. (2005). Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.. Journal of Natural Remedies, 5 (1), 41-45.
Size: 292.5Kb
Format: PDF

URI: http://hdl.handle.net/11441/67610

This work is under a Creative Commons License: 
Attribution-NonCommercial-NoDerivatives 4.0 Internacional

This item appears in the following Collection(s)