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Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density

 

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Opened Access Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
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Author: Pintado Losa, Cristina
Revilla Torres, María Elisa
Vizuete Chacón, María Luisa
García Cuervo, Luisa
Vitorica Ferrández, Francisco Javier
Ruano Caballero, Diego
Castaño Navarro, Angélica
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2011
Published in: Journal of Neuroimmunology, 238 (1-2), 44-51.
Document type: Article
Abstract: To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhile the induction of the anti-inflammatory IL-10 was inversely related to cell density. Accordingly, in vivo assays showed that after LPS-injection, iNOS expression was more intense in substantia nigra, a brain area showing specific susceptibility to neurodegeneration after microglia activation, whereas IL-10 expression was more sustained in striatum, an area resistant to damage. These results support that microglia density is pivotal to control the balance between pro- and anti-inflammatory factors release.
Cite: Pintado Losa, C., Revilla Torres, M.E., Vizuete Chacón, M.L., García Cuervo, L., Vitorica Ferrández, F.J., Ruano Caballero, D. y Castaño Navarro, A. (2011). Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density. Journal of Neuroimmunology, 238 (1-2), 44-51.
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URI: http://hdl.handle.net/11441/67291

DOI: 10.1016/j.jneuroim.2011.06.017

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