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Activation of Autophagy by Metals in Chlamydomonas reinhardtii

Opened Access Activation of Autophagy by Metals in Chlamydomonas reinhardtii

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Autor: Pérez Martín, Marta
Bably-Haas,Crysten E.
Pérez Pérez, Maria Esther
Andrés Garrido, Ascensión
Blaby, Ian K.
Merchant, Sabeeha S.
Crespo, José Luis
Fecha: 2015
Publicado en: Eukaryotic Cell, 14 (9), 964-973.
Tipo de documento: Artículo
Resumen: Autophagy is an intracellular self-degradation pathway by which eukaryotic cells recycle their own material in response to specific stress conditions. Exposure to high concentrations of metals causes cell damage, although the effect of metal stress on autophagy has not been explored in photosynthetic organisms. In this study, we investigated the effect of metal excess on autophagy in the model unicellular green alga Chlamydomonas reinhardtii. We show in cells treated with nickel an upregulation of ATG8 that is independent of CRR1, a global regulator of copper signaling in Chlamydomonas. A similar effect on ATG8 was observed with copper and cobalt but not with cadmium or mercury ions. Transcriptome sequencing data revealed an increase in the abundance of the protein degradation machinery, including that responsible for autophagy, and a substantial overlap of that increased abundance with the hydrogen peroxide response in cells treated with nickel ions. Thus, our results indicate that m...
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Cita: Pérez Martín, M., Bably-Haas, r.E., Pérez Pérez, M.E., Andrés Garrido, A., Blaby, I.K., Merchant, S.S. y Crespo, J.L. (2015). Activation of Autophagy by Metals in Chlamydomonas reinhardtii. Eukaryotic Cell, 14 (9), 964-973.
Tamaño: 1.850Mb
Formato: PDF

URI: http://hdl.handle.net/11441/65576

DOI: 10.1128/EC.00081-15

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