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Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems

Opened Access Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems

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Autor: García Hernández, Rosendo Miguel
Silva Hucha, Silvia
Morcuende Fernández, Sara R.
Rodríguez de la Cruz, Rosa María
Pastor Loro, Ángel Manuel
Benítez Temiño, Beatriz
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2017
Publicado en: Frontiers in Neuroscience, 11 (399), 1-12.
Tipo de documento: Artículo
Resumen: Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the present work was to characterize the presence of neurotrophins in extraocular motoneurons and muscles of the adult rat. We also compared these results with those obtained from other cranial motor systems, such as facial and hypoglossal, which indeed suffer neurodegeneration. Immunocytochemical analysis was used to describe the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in oculomotor, trochlear, abducens, facial, and hypoglossal nuclei of adult rats, and Western blots were used to describe the presence of neurotrophins in extraocular, facial (buccinator), and tongue muscles, which are innervated by the above-mentioned motoneurons. In brainstem samples, brain-derived neurotrophic factor was present both in extraocular and facial motoneuron somata, and to a lesser degree, in hypoglossal motoneurons. Neurotrophin-3 was presen...
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Cita: García Hernández, R.M., Silva Hucha, S., Morcuende Fernández, S.R., Rodríguez de la Cruz, R.M., Pastor Loro, Á.M. y Benítez Temiño, B. (2017). Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems. Frontiers in Neuroscience, 11 (399), 1-12.
Tamaño: 10.70Mb
Formato: PDF

URI: http://hdl.handle.net/11441/65507

DOI: 10.3389/fnins.2017.00399

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