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Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems

Opened Access Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems
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Autor: Ardanuy, Carmen
Liñares, Josefina
Domínguez, María Ángeles
Hernández Allés, Santiago
Benedí, Vicente J.
Martínez Martínez, Luis
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1998-07-01
Publicado en: Antimicrobial Agents and Chemotherapy, 42 (7), 1636-1640.
Tipo de documento: Artículo
Resumen: Fifteen isolates of Klebsiella pneumoniae producing extended-spectrum β-lactamases (ESBLs) isolated during a nosocomial outbreak were studied. The strains belonged to the same clonal type, as shown by pulsed-field gel electrophoretic analysis of chromosomal DNA. All the isolates were resistant to extended-spectrum cephalosporins, aztreonam, gentamicin, and fluoroquinolones and were susceptible to carbapenems, tobramycin, netilmicin, and amikacin. None of the isolates expressed the OmpK36 porin. Eight isolates, for which the MICs of cefoxitin were ≤64 μg/ml, showed a diminished level or no expression of a 35-kDa porin. The MICs of meropenem, cefotaxime, and cefpirome were three to eight times higher for porin- deficient isolates than for isolates expressing the 35-kDa porin, but the MICs of imipenem increased two times for porin-deficient isolates compared to those for isolates expressing the porin. This MIC increase reverted to a level similar to that for the parental strain when pori...
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Cita: Ardanuy, C., Liñares, J., Domínguez, M.Á., Hernández Allés, S., Benedí, V.J. y Martínez Martínez, L. (1998). Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems. Antimicrobial Agents and Chemotherapy, 42 (7), 1636-1640.
Tamaño: 990.4Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65010

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