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Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes

Opened Access Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes
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Autor: Pascual Hernández, Álvaro
García Luque, Isabel
Conejo Gonzalo, Mª Carmen
Perea Pérez, Evelio José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1993-01-01
Publicado en: Antimicrobial Agents and Chemotherapy, 37 (2), 187-190.
Tipo de documento: Artículo
Resumen: The penetration of fluconazole into human polymorphonuclear leukocytes (PMNs) and tissue culture epithelial cells (McCoy) was evaluated. At different extracellular concentrations (0.5 to 10 mg/liter), fluconazole reached cell-associated concentrations greater than the extracellular ones in either human PMNs (intracellular concentration to extracellular concentration ratio, ≥2.2) or McCoy cells (intracellular concentration to extracellular concentration ratio, ≥1.3). The uptake of fluconazole by PMNs was rapid and reversible but was not energy dependent. The intracellular penetration of fluconazole was not affected by environmental pH or temperature. Ingestion of opsonized zymosan and opsonized Candida albicans did not significantly increase the amount of PMN-associated fluconazole. At therapeutic extracellular concentrations, the intracellular activity of fluconazole against C. albicans in PMNs was significantly lower than that of amphotericin B. It was concluded that fluconazole reac...
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Cita: Pascual Hernández, Á., García Luque, I., Conejo Gonzalo, M.C. y Perea Pérez, E.J. (1993). Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 37 (2), 187-190.
Tamaño: 778.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65008

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