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Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains

Opened Access Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
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Autor: Martínez Martínez, Luis
García Luque, Isabel
Ballesta Mudarra, Sofía
Benedí, Vicente J.
Hernández Allés, Santiago
Pascual Hernández, Álvaro
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1998-07-01
Publicado en: Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
Tipo de documento: Artículo
Resumen: The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.
Cita: Martínez Martínez, L., García Luque, I., Ballesta Mudarra, S., Benedí, V.J., Hernández Allés, S. y Pascual Hernández, Á. (1998). Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
Tamaño: 134.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65006

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