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Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains

 

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Opened Access Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
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Author: Martínez Martínez, Luis
García Luque, Isabel
Ballesta Mudarra, Sofía
Benedí, Vicente J.
Hernández Allés, Santiago
Pascual Hernández, Álvaro
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 1998-07-01
Published in: Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
Document type: Article
Abstract: The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.
Cite: Martínez Martínez, L., García Luque, I., Ballesta Mudarra, S., Benedí, V.J., Hernández Allés, S. y Pascual Hernández, Á. (1998). Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains. Antimicrobial Agents and Chemotherapy, 42 (7), 1850-1852.
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URI: http://hdl.handle.net/11441/65006

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