Repositorio de producción científica de la Universidad de Sevilla

Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells

 

Advanced Search
 
Opened Access Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells
Cites

Show item statistics
Icon
Export to
Author: Pascual Hernández, Álvaro
Ballesta Mudarra, Sofía
García Luque, Isabel
Perea Pérez, Evelio José
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2002-12-01
Published in: Antimicrobial Agents and Chemotherapy, 46 (12), 4013-4015.
Document type: Article
Abstract: The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ones in both types of cell. The uptake was rapid and not saturable and was affected by environmental temperature and cell viability. Linezolid showed slight intracellular activity against Staphylococcus epidermidis at high extracellular concentrations.
Cite: Pascual Hernández, Á., Ballesta Mudarra, S., García Luque, I. y Perea Pérez, E.J. (2002). Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells. Antimicrobial Agents and Chemotherapy, 46 (12), 4013-4015.
Size: 64.11Kb
Format: PDF

URI: http://hdl.handle.net/11441/65004

DOI: 10.1128/AAC.46.12.4013-4015.2002

See editor´s version

This work is under a Creative Commons License: 
Attribution-NonCommercial-NoDerivatives 4.0 Internacional

This item appears in the following Collection(s)