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Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits

 

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Opened Access Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits
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Author: López Cortés, Luis Fernando
Ruiz Valderas, Rosa
Lucero Muñoz, María Jesús
Cordero, Elisa
Pastor Ramos, M. T.
Márquez, Javier
Department: Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
Universidad de Sevilla. Departamento de Medicina
Date: 2000-03-01
Published in: Antimicrobial Agents and Chemotherapy, 44 (3), 756-759.
Document type: Article
Abstract: Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two- compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels.
Cite: López Cortés, L.F., Ruiz Valderas, R., Lucero Muñoz, M.J., Cordero, E., Pastor Ramos, M.T. y Márquez, J. (2000). Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits. Antimicrobial Agents and Chemotherapy, 44 (3), 756-759.
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URI: http://hdl.handle.net/11441/64863

DOI: 10.1128/AAC.44.3.756-759.2000

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