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In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC

dc.creatorBriales, Alejandraes
dc.creatorRodríguez Martínez, José Manueles
dc.creatorGonzález Velasco, Carmenes
dc.creatorDíaz de Alba, Paulaes
dc.creatorDomínguez Herrera, Juan M.es
dc.creatorPachón Díaz, Jerónimoes
dc.creatorPascual Hernández, Álvaroes
dc.date.accessioned2017-09-28T16:59:22Z
dc.date.available2017-09-28T16:59:22Z
dc.date.issued2011-03-01
dc.identifier.citationBriales, A., Rodríguez Martínez, J.M., González Velasco, C., Díaz de Alba, P., Domínguez Herrera, J.M., Pachón, J. y Pascual Hernández, Á. (2011). In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. Antimicrobial Agents and Chemotherapy, 55 (3), 1266-1269.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/64858
dc.description.abstractThis article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants.es
dc.description.sponsorshipMinisterio de Sanidad y Consumo y Instituto de Salud Carlos III PI060580es
dc.description.sponsorshipConsejería de Innovación Ciencia y Empresa Junta de Andalucía P07-CTS-02908es
dc.description.sponsorshipMinisterio de Sanidad y Consumo y Instituto de Salud Carlos III-FEDER y Spanish Network for Research in Infectious Diseases REIPI RD06/0008es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 55 (3), 1266-1269.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIn vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parCes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDPI060580es
dc.relation.projectIDP07-CTS-02908es
dc.relation.projectIDREIPI RD06/0008es
dc.relation.publisherversionhttp://dx.doi.org/10.1128/AAC.00927-10es
dc.identifier.doi10.1128/AAC.00927-10es
idus.format.extent4 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen55es
dc.publication.issue3es
dc.publication.initialPage1266es
dc.publication.endPage1269es

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