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In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC

Opened Access In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC

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Autor: Briales, Alejandra
Rodríguez Martínez, José Manuel
González Velasco, Carmen
Díaz de Alba, Paula
Domínguez Herrera, Juan M.
Pachón Díaz, Jerónimo
Pascual Hernández, Álvaro
Departamento: Universidad de Sevilla. Departamento de Microbiología
Universidad de Sevilla. Departamento de Medicina
Fecha: 2011-03-01
Publicado en: Antimicrobial Agents and Chemotherapy, 55 (3), 1266-1269.
Tipo de documento: Artículo
Resumen: This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants.
Cita: Briales, A., Rodríguez Martínez, J.M., González Velasco, C., Díaz de Alba, P., Domínguez Herrera, J.M., Pachón, J. y Pascual Hernández, Á. (2011). In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. Antimicrobial Agents and Chemotherapy, 55 (3), 1266-1269.
Tamaño: 184.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64858

DOI: 10.1128/AAC.00927-10

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