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Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation

Opened Access Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation

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Autor: Forbes Hernandez, Tamara Yuliett
Giampieri, Francesca
Gasparrini, Massimiliano
Afrin, Sadia
Mazzoni, Luca
Cordero, Mario D.
Mezzetti, Bruno
Quiles, José L.
Battino, Maurizio
Departamento: Universidad de Sevilla. Departamento de Estomatología
Fecha: 2017-06-16
Tipo de documento: Artículo
Resumen: Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) hasa direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its possible repercussion on lipid metabolism in human hepatocellular carcinoma cells (HepG2). For such purpose, the lipid profile and the expression of proteins metabolically related to AMPK were determined on cells lysates. The results demonstrated that strawberry methanolic extract decreased total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglycerides levels (up to 0.50-, 0.30-, and 0.40-fold, respectively) while it stimulated the p-AMPK/AMPK expression (up to 3.06-fold), compare...
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Tamaño: 4.018Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64721

DOI: 10.3390/nu9060621

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