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Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation

 

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Opened Access Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
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Author: Pintado Losa, Cristina
Macías Benítez, Sandra
Domínguez Martín, Helena
Castaño Navarro, Angélica
Ruano Caballero, Diego
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2017
Published in: Scientific Reports, 7 (8100), 1-12.
Document type: Article
Abstract: Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activi...
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Cite: Pintado Losa, C., Macías, S., Domínguez Martín, H., Castaño Navarro, A. y Ruano Caballero, D. (2017). Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation. Scientific Reports, 7 (8100), 1-12.
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Format: PDF

URI: http://hdl.handle.net/11441/64532

DOI: 10.1038/s41598-017-08722-3

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