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Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB

Opened Access Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB

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Autor: Miguel Carrasco, José Luis
Zambrano Sevilla, Sonia
Blanca Lobato, Antonio Jesús
Mate Barrero, Alfonso
Vázquez Cueto, Carmen María
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2010
Publicado en: Journal of Inflammation, 7, 21-.
Tipo de documento: Artículo
Resumen: Background. Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension. Methods. Left ventricle mRNA expression and plasma levels of pro-inflammatory (interleukin-1β (IL-1β) and IL-6) and anti-inflammatory (IL-10) cytokines, were measured in spontaneously hypertensive rats (SHR) and their control normotensive, Wistar-Kyoto (WKY) rats, with or without a 12-week treatment with captopril (80 mg/Kg/day; n = six animals per group). To understand the mechanisms involved in the effect of captopril, mRNA expression of ACE, angiotensin II type I receptor (AT1R) and p22phox (a subunit of NADPH oxidase), as well as NF-κB activation and expression, were measured in the left ventricle of these animals. Results. In SHR, the observed increases in blood pressures, heart rate, left ...
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Cita: Miguel Carrasco, J.L., Zambrano Sevilla, S., Blanca Lobato, A.J., Mate Barrero, A. y Vázquez Cueto, C.M. (2010). Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB. Journal of Inflammation, 7, 21-.
Tamaño: 782.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64195

DOI: 10.1186/1476-9255-7-21

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