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H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

Opened Access H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes

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Autor: Nadal Ribelles, Mariona
Mas, Glòria
Millán Zambrano, Gonzalo
Solé, Carme
Ammerer, Gustav
Chávez de Diego, Sebastián
Posas, Francesc
de Nadal, Eulàlia
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2015-03-26
Publicado en: Nucleic Acids Research, 43 (10), 4937-4949.
Tipo de documento: Artículo
Resumen: Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC chromatin remodeling complex to stress-responsive genes and rsc deficient cells display reduced induction of gene expression. Here we show that the absence of H3K4 methylation, either achieved by deletion of the SET1 methyltransferase or by amino acid substitution of H3K4, bypasses the requirement of RSC for stress-responsive gene expression. Monomethylation of H3K4 is specifically inhibiting RSC-independent chromatin remodeling and thus, it prevents osmostress-induced gene expression. The absence of H3K4 monomethylation permits that the association of alternative remodelers with stress-responsive genes and the Swr1 complex (SWR-C) is instrumental in the induction of gene expression upon stress. Accordingly, the absence of SWR-C or histone H2A.Z results in compromised ...
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Cita: Nadal Ribelles, M., Mas, G., Millán Zambrano, G., Solé, C., Ammerer, G., Chávez de Diego, S.,...,de Nadal, E. (2015). H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes. Nucleic Acids Research, 43 (10), 4937-4949.
Tamaño: 1.373Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64161

DOI: 10.1093/nar/gkv220

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