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Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

Opened Access Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

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Autor: Díaz Moreno, Irene
Hollingworth,David
Kelly, Geoff
Martin, Stephen
García Mayoral, María Flor
Fecha: 2010
Publicado en: Nucleic Acids Research, 38 (15), 5193-5205.
Tipo de documento: Artículo
Resumen: KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets.
Cita: Díaz Moreno, I., Hollingworth, a., Kelly, G., Martin, S. y García Mayoral, M.F. (2010). Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research, 38 (15), 5193-5205.
Tamaño: 18.37Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64106

DOI: 10.1093/nar/gkq216

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