Repositorio de producción científica de la Universidad de Sevilla

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

 

Advanced Search
 
Opened Access Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
Cites

Show item statistics
Icon
Export to
Author: Díaz Moreno, Irene
Hollingworth, David
Kelly, Geoff
Martin, Stephen
García Mayoral, María Flor
Date: 2010
Published in: Nucleic Acids Research, 38 (15), 5193-5205.
Document type: Article
Abstract: KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets.
Cite: Díaz Moreno, I., Hollingworth, a., Kelly, G., Martin, S. y García Mayoral, M.F. (2010). Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research, 38 (15), 5193-5205.
Size: 18.37Mb
Format: PDF

URI: http://hdl.handle.net/11441/64106

DOI: 10.1093/nar/gkq216

See editor´s version

This work is under a Creative Commons License: 
Attribution-NonCommercial-NoDerivatives 4.0 Internacional

This item appears in the following Collection(s)