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Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications

Opened Access Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications

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Autor: Rivas Marchena, David
Olmo Fernández, Alberto
Miguel, J.A.
Martínez, Mar
Huertas Sánchez, Gloria
Yúfera García, Alberto
Departamento: Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo
Universidad de Sevilla. Departamento de Tecnología Electrónica
Fecha: 2017
Publicado en: Sensors, 17 (8), 1-11.
Tipo de documento: Artículo
Resumen: To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. A mathematical model was developed to analytically describe the histological composition of the neointima, employing its conductivity and permittivity data. The bioimpedance model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software. A satisfactory correlation between the analytical model and FEA simulation was achieved in most cases, detecting some deviations introduced by the thin “double layer” that separates the neointima and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied to c...
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Cita: Rivas Marchena, D., Olmo Fernández, A., Miguel, J.A., Martínez, M., Huertas Sánchez, G. y Yúfera García, A. (2017). Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications. Sensors, 17 (8), 1-11.
Tamaño: 4.743Mb
Formato: PDF

URI: http://hdl.handle.net/11441/64036

DOI: 10.3390/s17081737

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