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Osteoblasts Interaction with PLGA Membranes Functionalized with Titanium Film Nanolayer by PECVD. In vitro Assessment of Surface Influence on Cell Adhesion during Initial Cell to Material Interaction

Opened Access Osteoblasts Interaction with PLGA Membranes Functionalized with Titanium Film Nanolayer by PECVD. In vitro Assessment of Surface Influence on Cell Adhesion during Initial Cell to Material Interaction

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Autor: Terriza Fernández, Antonia
Vilches Pérez, José Ignacio
González Caballero, Juan Luis
De la Orden, Emilio
Yubero Valencia, Francisco
Barranco Quero, Angel
Rodríguez González Elipe, Agustín
Vilches, José
Salido, Mercedes
Fecha: 2014-03
Publicado en: Materials, 7 (3), 1687-1708.
Tipo de documento: Artículo
Resumen: New biomaterials for Guided Bone Regeneration (GBR), both resorbable and non-resorbable, are being developed to stimulate bone tissue formation. Thus, the in vitro study of cell behavior towards material surface properties turns a prerequisite to assess both biocompatibility and bioactivity of any material intended to be used for clinical purposes. For this purpose, we have developed in vitro studies on normal human osteoblasts (HOB®) HOB® osteoblasts grown on a resorbable Poly (lactide-co-glycolide) (PLGA) membrane foil functionalized by a very thin film (around 15 nm) of TiO2 (i.e., TiO2/PLGA membranes), designed to be used as barrier membrane. To avoid any alteration of the membranes, the titanium films were deposited at room temperature in one step by plasma enhanced chemical vapour deposition. Characterization of the functionalized membranes proved that the thin titanium layer completely covers the PLGA foils that remains practically unmodified in their interior after the deposit...
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Cita: Terriza Fernández, A., Vilches Pérez, J.I., González Caballero, J.L., De la Orden, E., Yubero Valencia, F., Barranco Quero, A.,...,Salido, M. (2014). Osteoblasts Interaction with PLGA Membranes Functionalized with Titanium Film Nanolayer by PECVD. In vitro Assessment of Surface Influence on Cell Adhesion during Initial Cell to Material Interaction. Materials, 7 (3), 1687-1708.
Tamaño: 6.428Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63954

DOI: 10.3390/ma7031687

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