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A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice

Opened Access A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice

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Autor: Cañete, Ana
Carmona, Rita
Ariza, Laura
Sánchez, Mª José
Rojas, Anabel
Muñoz Chápuli, Ramón
Fecha: 2017
Publicado en: Haematologica, 102 (4), 647-655.
Tipo de documento: Artículo
Resumen: GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are critically involved in hematopoiesis. An enhancer (G2) of the mouse Gata4 gene directs its expression throughout the lateral mesoderm and the allantois, beginning at embryonic day 7.5, becoming restricted to the septum transversum by embryonic day 10.5, and disappearing by midgestation. We have studied the developmental fate of the G2-Gata4 cell lineage using a G2-Gata4Cre;R26REYFP mouse line. We found a substantial number of YFP+ hematopoietic cells of lymphoid, myeloid and erythroid lineages in embryos. Fetal CD41+ /cKit+ /CD34+ and Lin– /cKit+ /CD31+ YFP+ hematopoietic progenitors were much more abundant in the placenta than in the aorta-gonad-mesonephros area. They were clonogenic in the MethoCult assay and fully reconstituted hematopoiesis in myeloablated mice. YFP+ cells represented about 20% of the hematopoietic system of adult mice. Adult YFP+...
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Cita: Cañete, A., Carmona, R., Ariza, L., Sánchez, M.J., Rojas, A. y Muñoz Chápuli, R. (2017). A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice. Haematologica, 102 (4), 647-655.
Tamaño: 3.807Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63935

DOI: 10.3324/haematol.2016.155812

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