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Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition

Opened Access Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition

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Autor: Terriza Fernández, Antonia
Vilches Pérez, José Ignacio
De la Orden, Emilio
Yubero Valencia, Francisco
González Caballero, Juan Luis
Rodríguez González-Elipe, Agustín
Vilches, José
Salido, Mercedes
Fecha: 2014
Publicado en: BioMed Research International, 253590, 1-10.
Tipo de documento: Artículo
Resumen: The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for clinical use, hopefully enhancing bone regeneration. Bioactive inorganic materials, such as silica, have been suggested to improve the bioactivity of synthetic biopolymers. An in vitro study on HOB human osteoblasts was performed to assess biocompatibility and bioactivity of SiO2 functionalized poly(lactide-co-glycolide) (PLGA) membranes, prior to clinical use. A 15 nm SiO2 layer was deposited by plasma enhanced chemical vapour deposition (PECVD), onto a resorbable PLGA membrane. Samples were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and infrared spectroscopy (FT-IR). HOB cells were seeded on sterilized test surfaces where cell morphology, spreading, actin cytoskeletal organization, and focal adhesion exp...
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Cita: Terriza Fernández, A., Vilches Pérez, J.I., De la Orden, E., Yubero Valencia, F., González Caballero, J.L., Rodríguez González-Elipe, A.,...,Salido, M. (2014). Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition. BioMed Research International, 253590, 1-10.
Tamaño: 2.052Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63901

DOI: 10.1155/2014/253590

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