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Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles

Opened Access Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles

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Autor: Martínez Martínez, Luis
Conejo Gonzalo, Mª Carmen
Pascual Hernández, Álvaro
Hernández Allés, Santiago
Ramírez de Arellano Ramos, E.
Benedí, Vicente J.
Perea Pérez, Evelio José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2000-09-06
Publicado en: Antimicrobial Agents and Chemotherapy, 44 (9), 2534-2536.
Tipo de documento: Artículo
Resumen: Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 μg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 μg/ml) and imipenem (MICs, 0.125 to 0.25 μg/ml). Resistance to β-lactams was related to high-level production of AmpC β-lactamase and loss of OmpF porin.
Cita: Martínez Martínez, L., Conejo Gonzalo, M.C., Pascual Hernández, Á., Hernández Allés, S., Ramírez de Arellano Ramos, E., Benedí, V.J. y Perea Pérez, E.J. (2000). Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles. Antimicrobial Agents and Chemotherapy, 44 (9), 2534-2536.
Tamaño: 192.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/63826

DOI: 10.1128/AAC.44.9.2534-2536.2000

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