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The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice

Opened Access The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice

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Autor: Romero Zerbo, Silvana Y.
Ruz Maldonado, Inmaculada
Espinosa Jiménez, Vanesa
Cobo Vuilleumier, Nadia
Gauthier, Benoit R.
Fecha: 2017
Publicado en: Scientific Reports, 7 (3946)
Tipo de documento: Artículo
Resumen: LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology is still unclear. It has been associated with anti-obesity actions in obese rats. However, its role in preventing type 2 diabetes (T2D) onset have not been studied yet. Given CB1 receptors remain as potential pharmacological targets to fight against obesity and T2D, we wanted to explore the metabolic impact of this compound in an animal model of obesity and pre-diabetes as well as the lack of relevant actions in related central processes such as anxiety. C57BL/6J mice were rendered obese and pre-diabetic by feeding a high-fat diet for 15 weeks and then treated with LH-21 or vehicle for two weeks. Food intake, body weight and glucose handling were assessed, together with other relevant parameters. Behavioural performance was evaluated by the open field test and the elevated plus maze. LH-21 did not affect food intake nor body weight but it improved glucose handling, d...
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Cita: Romero Zerbo, S.Y., Ruz Maldonado, I., Espinosa Jiménez, V., Cobo Vuilleumier, N. y Gauthier, B.R. (2017). The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice. Scientific Reports, 7 (3946)
Tamaño: 7.064Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63798

DOI: 10.1038/s41598-017-03292-w

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