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PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

Opened Access PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

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Autor: Mellado Gil, José Mauel
Jiménez Moreno, Carmen María
Martín Montalvo, Alejandro
Álvarez Mercado, Ana Isabel
Fecha: 2016
Publicado en: Diabetologia, 59, 755-765.
Tipo de documento: Artículo
Resumen: Aims/hypothesis A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteriorating glycaemic control associated with diabetes mellitus. The aims of the current study were to investigate the therapeutic potential of such a target, the islet-enriched and diabetes-linked transcription factor paired box 4 (PAX4), to restrain experimental autoimmune diabetes (EAD) in the RIP-B7.1 mouse model background and to characterise putative cellular mechanisms associated with preserved BCM. Methods Two groups of RIP-B7.1 mice were genetically engineered to: (1) conditionally express either PAX4 (BPTL) or its diabetes-linked mutant variant R129W (mutBPTL) using doxycycline (DOX); and (2) constitutively express luciferase in beta cells through the use of RIP. Mice were treated or not with DOX, and EAD was induced by immunisation with a murine pr...
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Cita: Mellado Gil, J.M., Jiménez Moreno, C.M., Martín Montalvo, A. y Álvarez Mercado, A.I. (2016). PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus. Diabetologia, 59, 755-765.
Tamaño: 1.983Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63783

DOI: 10.1007/s00125-016-3864-0

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