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Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency

Opened Access Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency

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Autor: Gallastegui, Edurne
Millán Zambrano, Gonzalo
Terme, Jean Michel
Chávez de Diego, Sebastián
Jordan, Albert
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2011-04
Publicado en: Journal of Virology, 85 (7), 3187-3202.
Tipo de documento: Artículo
Resumen: The establishment of a stable reservoir of latently infected cells allows HIV to persist in the host. Usually, HIV infection of T cells results in integration of the viral genome, with a preference for regions in the human genome containing active genes, viral expression, and production of new viruses. However, in rare cases T cells become latently infected, and this is presumed to be due to a combination of two factors: integrated viruses are not efficiently transcribed and infected T cells revert to a resting memory state. HIV latency has been associated with provirus integration in regions of constitutive heterochromatin, gene deserts, or very highly expressed genes. We have investigated the transcriptional consequences of latent HIV integration into cellular genes and the involvement of chromatin reassembly factors (CRFs) in the transcriptional interference that a host gene exerts on the integrated cryptic HIV promoter. Chimeric transcripts containing sequences from the host gene ...
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Cita: Gallastegui, E., Millán Zambrano, G., Terme, J.M., Chávez de Diego, S. y Jordan, A. (2011). Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency. Journal of Virology, 85 (7), 3187-3202.
Tamaño: 2.263Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63474

DOI: 10.1128/JVI.01920-10

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