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Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa

 

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Opened Access Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa
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Author: Conejo Gonzalo, Mª Carmen
García Luque, Isabel
Martínez Martínez, Luis
Picabea de la Peña, Leandro
Pascual Hernández, Álvaro
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2003-07-01
Published in: Antimicrobial Agents and Chemotherapy, 47 (7), 2313-2315.
Document type: Article
Abstract: The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.
Cite: Conejo Gonzalo, M.C., García Luque, I., Martínez Martínez, L., Picabea de la Peña, L. y Pascual Hernández, Á. (2003). Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 47 (7), 2313-2315.
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URI: http://hdl.handle.net/11441/63346

DOI: 10.1128/AAC.47.7.2313-2315.2003

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