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Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1

 

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Opened Access Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
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Author: Pascual Hernández, Álvaro
Rodríguez Martínez, José Manuel
González Velasco, Carmen
García Luque, Isabel
Cano, María Eliecer
Martínez Martínez, Luis
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2007-06-01
Published in: Antimicrobial Agents and Chemotherapy, 51 (6), 2236-2239.
Document type: Article
Abstract: The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.
Cite: Pascual Hernández, Á., Rodríguez Martínez, J.M., González Velasco, C., García Luque, I., Cano, M.E. y Martínez Martínez, L. (2007). Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. Antimicrobial Agents and Chemotherapy, 51 (6), 2236-2239.
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URI: http://hdl.handle.net/11441/63343

DOI: 10.1128/AAC.01444-06

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