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European multicenter study of the LIAISON automated diagnostic system for determination of Toxoplasma gondii-specific immunoglobulin G (IgG) and IgM and the IgG avidity index

Opened Access European multicenter study of the LIAISON automated diagnostic system for determination of Toxoplasma gondii-specific immunoglobulin G (IgG) and IgM and the IgG avidity index

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Autor: Petersen, Eskild
Borobio Enciso, María Victoria
Guy, Edward
Liesenfeld, Oliver
Meroni, Valeria
Naessens, Anne
Spranzi, Emma
Thulliez, Philippe
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2005
Publicado en: Journal of Clinical Microbiology, 43 (4), 1570-1574.
Tipo de documento: Artículo
Resumen: The LIAISON system is a fully automated system based on chemiluminescence and antigen bound to magnetic microparticles. The system allows fast and precise measurement of Toxoplasma-specific immunoglobulin G (IgG) and IgM antibody levels and measurement of the IgG avidity index even at low levels of Toxoplasma-specific IgG antibodies in a single step without manual interference. Seven European centers participated in a multicenter evaluation of the LIAISON system. The sensitivity and specificity of the LIAISON system compared to the Sabin-Feldman dye test were 99.3 and 96.8%, respectively. In a comparison of the LIAISON Toxoplasma-specific IgM assay with an immunosorbent agglutination assay, the LIAISON assay had a sensitivity of 96.7% and a specificity of 95.4%. The LIAISON IgG assay showed agreements of 91, 100, and 100% with the AXSYM IgG (Abbott), VIDAS IgG (bioMérieux), and Platelia IgG (Bio-Rad) assays, respectively. The LIAISON IgM assay showed agreements of 95% with the AXSYM I...
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Cita: Petersen, E., Borobio Enciso, M.V., Guy, E., Liesenfeld, O., Meroni, V., Naessens, A.,...,Thulliez, P. (2005). European multicenter study of the LIAISON automated diagnostic system for determination of Toxoplasma gondii-specific immunoglobulin G (IgG) and IgM and the IgG avidity index. Journal of Clinical Microbiology, 43 (4), 1570-1574.
Tamaño: 87.09Kb
Formato: PDF

URI: http://hdl.handle.net/11441/63340

DOI: 10.1128/JCM.43.4.1570-1574.2005

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