Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost

Cauce, Alejandro; Briales, Alejandra; Rodríguez Rojas, Alexandro; Costas, Coloma; Pascual Hernández, Álvaro; Blázquez, Jesús

doi:10.1128/AAC.06122-11

Artículo

dc.creator	Cauce, Alejandro	es
dc.creator	Briales, Alejandra	es
dc.creator	Rodríguez Rojas, Alexandro	es
dc.creator	Costas, Coloma	es
dc.creator	Pascual Hernández, Álvaro	es
dc.creator	Blázquez, Jesús	es
dc.date.accessioned	2017-07-27T11:37:43Z
dc.date.available	2017-07-27T11:37:43Z
dc.date.issued	2012-05-01
dc.identifier.citation	Cauce, A., Briales, A., Rodríguez Rojas, A., Costas, C., Pascual Hernández, Á. y Blázquez, J. (2012). Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost. Antimicrobial Agents and Chemotherapy, 56 (5), 2767-2769.
dc.identifier.issn	0066-4804 (impreso)	es
dc.identifier.issn	1098-6596 (electrónico)	es
dc.identifier.uri	http://hdl.handle.net/11441/63338
dc.description.abstract	To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was performed. Major results are that (i) no clinical level of resistance is achieved by overexpressing chromosomal genes, except murA; (ii) this level is reached at a low fitness cost; and (iii) this cost is much lower than that imposed by other mutations conferring fosfomycin resistance.	es
dc.description.sponsorship	Ministerio de Ciencia e Innovación y Instituto de Salud Carlos III PI10/00105	es
dc.description.sponsorship	Spanish Network for Research on Infectious Diseases REIPI RD06/0008	es
dc.format	application/pdf	es
dc.language.iso	eng	es
dc.publisher	American Society for Microbiology	es
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy, 56 (5), 2767-2769.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Microbiología	es
dc.relation.projectID	PI10/00105	es
dc.relation.projectID	REIPI RD06/0008	es
dc.relation.publisherversion	http://dx.doi.org/10.1128/AAC.06122-11	es
dc.identifier.doi	10.1128/AAC.06122-11	es
idus.format.extent	3 p.	es
dc.journaltitle	Antimicrobial Agents and Chemotherapy	es
dc.publication.volumen	56	es
dc.publication.issue	5	es
dc.publication.initialPage	2767	es
dc.publication.endPage	2769	es
dc.contributor.funder	Ministerio de Ciencia e Innovación (MICIN). España

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