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Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance

dc.creatorDoménech Sánchez, Antonioes
dc.creatorMartínez Martínez, Luises
dc.creatorHernández Allés, Santiagoes
dc.creatorConejo Gonzalo, Mª Carmenes
dc.creatorPascual Hernández, Álvaroes
dc.creatorTomás, Juan M.es
dc.creatorAlbertí, Sebastiánes
dc.creatorBenedí, Vicente J.es
dc.date.accessioned2017-07-27T11:35:15Z
dc.date.available2017-07-27T11:35:15Z
dc.date.issued2003-10-01
dc.identifier.citationDoménech Sánchez, A., Martínez Martínez, L., Hernández Allés, S., Conejo Gonzalo, M.C., Pascual Hernández, Á., Tomás, J.M.,...,Benedí, V.J. (2003). Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance. Antimicrobial Agents and Chemotherapy, 47 (10), 1803-1803.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/63333
dc.description.abstractTo investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various antibiotics and the frequency of mutation to increased cefoxitin or meropenem resistance of the strains CSUB10S (expressing only OmpK36), CSUB10R (lacking OmpK35 and OmpK36), and their derived isogenic insertion-duplication mutants deficient in LamB. Expression of LamB was indispensable in order for CSUB10S to lose OmpK36 and become resistant to cefoxitin, while in CSUB10R, LamB deficiency promoted increased resistance to carbapenem.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 47 (10), 1803-1803.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleRole of Klebsiella pneumoniae LamB porin in antimicrobial resistancees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
dc.relation.publisherversionel http://dx.doi.org/10.1128/AAC.01441-10es
dc.identifier.doi10.1128/AAC.01441-10es
idus.format.extent3 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen47es
dc.publication.issue10es
dc.publication.initialPage1803es
dc.publication.endPage1803es

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