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Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway

Opened Access Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway

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Autor: Quintero, María José
Muro Pastor, Alicia María
Herrero Moreno, Antonia
Flores García, Enrique
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2000
Publicado en: Journal of Bacteriology, 182 (4), 1008-1015.
Tipo de documento: Artículo
Resumen: Cells of the unicellular cyanobacterium Synechocystis sp. strain PCC 6803 supplemented with micromolar concentrations of L-[14C]arginine took up, concentrated, and catabolized this amino acid. Metabolism of L[14]arginine generated a set of labeled amino acids that included argininosuccinate, citrulline, glutamate, glutamine, ornithine, and proline. Production of [14C]ornithine preceded that of [14C]citrulline, and the patterns of labeled amino acids were similar in cells incubated with L- [14C] ornithine, suggesting that the reaction of arginase, rendering ornithine and urea, is the main initial step in arginine catabolism. Ornithine followed two metabolic pathways: (i) conversion into citrulline, catalyzed by ornithine carbamoyltransferase, and then, with incorporation of aspartate, conversion into argininosuccinate, in a sort of urea cycle, and (ii) a sort of arginase pathway rendering glutamate (and glutamine) via Δ1pyrroline-5-carboxylate and proline. Consistently with the propose...
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Cita: Quintero, M.J., Muro Pastor, A.M., Herrero, A. y Flores García, E. (2000). Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway. Journal of Bacteriology, 182 (4), 1008-1015.
Tamaño: 1.498Mb
Formato: PDF

URI: http://hdl.handle.net/11441/63121

DOI: 10.1128/JB.182.4.1008-1015.2000

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