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A TolC-like protein is required for heterocyst development in anabaena sp. strain PCC 7120

Opened Access A TolC-like protein is required for heterocyst development in anabaena sp. strain PCC 7120

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Autor: Moslavac, Suncana
Nicolaisen, Kerstin
Mirus, Oliver
Al Dehni, Fadi
Pernil, Rafael
Flores García, Enrique
Maldener, Iris
Schleiff, Enrico
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2007
Publicado en: Journal of Bacteriology, 189 (21), 7887-7895.
Tipo de documento: Artículo
Resumen: The filamentous cyanobacterium Anabaena sp. strain PCC 7120 forms heterocysts in a semiregular pattern when it is grown on N2 as the sole nitrogen source. The transition from vegetative cells to heterocysts requires marked metabolic and morphological changes. We show that a trimeric pore-forming outer membrane β-barrel protein belonging to the TolC family, Alr2887, is up-regulated in developing heterocysts and is essential for diazotrophic growth. Mutants defective in Alr2887 did not form the specific glycolipid layer of the heterocyst cell wall, which is necessary to protect nitrogenase from external oxygen. Comparison of the glycolipid contents of wild-type and mutant cells indicated that the protein is not involved in the synthesis of glycolipids but might instead serve as an exporter for the glycolipid moieties or enzymes involved in glycolipid attachment. We propose that Alr2887, together with an ABC transporter like DevBCA, is part of a protein export system essential for assemb...
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Cita: Moslavac, S., Nicolaisen, K., Mirus, O., Al Dehni, F., Pernil, R., Flores García, E.,...,Schleiff, E. (2007). A TolC-like protein is required for heterocyst development in anabaena sp. strain PCC 7120. Journal of Bacteriology, 189 (21), 7887-7895.
Tamaño: 543.6Kb
Formato: PDF

URI: http://hdl.handle.net/11441/63118

DOI: 10.1128/JB.00750-07

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