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Melatonin-synthesizing enzymes and melatonin receptor in rat thyroid cells

Opened Access Melatonin-synthesizing enzymes and melatonin receptor in rat thyroid cells
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Autor: García Marín, Mª del Rocío
Miguel Rodríguez, Manuel de
Fernández-Santos, José María
Carrillo Vico, Antonio
Utrilla Alcolea, José Carmelo
Morillo Bernal, Jesús
Díaz-Parrado, Eduardo
Rodríguez-Prieto, Ismael
Guerrero Montávez, Juan Miguel
Martín-Lacave, Inés
Departamento: Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica
Universidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunología
Instituto de Biomedicina de Sevilla (IBIS)
Universidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunología
Fecha: 2012-11
Publicado en: Histology and Histopathology, 27 (11), 1429-1438.
Tipo de documento: Artículo
Resumen: Melatonin is an indoleamine with a wide spectrum of biological activities other than transmitting photoperiod information, including antioxidant, oncostatic, anti-aging and immunomodulatory properties. Although melatonin is synthesized mainly in the pineal gland, other tissues have the same capacity. In the present study, we examined whether two key enzymes in melatonin biosynthesis, arylalkylamine Nacetyltransferase (AANAT) and hydroxyindole-Omethyltransferase (HIOMT) and its receptor MT1 are expressed in the two endocrine thyroid cells of the rat, follicular cells and C cells. Reverse Transcriptase polymerase chain reaction analyses demonstrated that both AANAT and HIOMT mRNAs are expressed in the rat thyroid C-cells, and MT1 expression has been detected in C cells and follicular cells. Immunofluorescence revealed that AANAT protein is localized in C-cell cytoplasm, and MT1 protein in both cell populations. These findings demonstrate that the rat thyroid expresses AANAT, HIOMT, and...
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Cita: García Marín, M.d.R., Miguel Rodríguez, M.d., Fernández-Santos, J.M., Carrillo Vico, A., Utrilla, J.C., Morillo Bernal, J.,...,Martín-Lacave, I. (2012). Melatonin-synthesizing enzymes and melatonin receptor in rat thyroid cells. Histology and Histopathology, 27 (11), 1429-1438.
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URI: http://hdl.handle.net/11441/61714

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