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Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital

 

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dc.creator Valencia, R. es
dc.creator Arroyo, Luis A. es
dc.creator Conde Herrera, Manuel es
dc.creator Aldana, Josefa M. es
dc.creator Torres Sánchez, María José es
dc.creator Fernández-Cuenca, Felipe es
dc.creator Garnacho Montero, José es
dc.creator Cisneros, José Miguel es
dc.creator Ortiz Leyba, Carlos es
dc.creator Pachón Díaz, Jerónimo es
dc.creator Aznar Martín, Javier es
dc.date.accessioned 2017-06-26T17:01:38Z
dc.date.available 2017-06-26T17:01:38Z
dc.date.issued 2009-03
dc.identifier.issn 0899823X es
dc.identifier.uri http://hdl.handle.net/11441/61522
dc.description.abstract TO describe what is, to our knowledge, the first nosocomial outbreak of infection with pan–drug-resistant (including colistin-resistant) Acinetobacter baumannii, to determine the risk factors associated with these types of infections, and to determine their clinical impact. Nested case-control cohort study and a clinical-microbiological study. A 1,521-bed tertiary care university hospital in Seville, Spain. Case patients were inpatients who had a pan-drug-resistant A. baumannii isolate recovered from a clinical or surveillance sample obtained at least 48 hours after admission to an intensive care unit (ICU) during the time of the epidemic outbreak. Control patients were patients who were admitted to any of the “boxes” (ie, rooms that partition off a distinct area for a patient's bed and the equipment needed to care for the patient) of an ICU for at least 48 hours during the time of the epidemic outbreak. All the clinical isolates had similar antibiotic susceptibility patterns (ie, they were resistant to all the antibiotics tested, including Colistin), and, on the basis of repetitive extragenic palindromic-polymerase chain reaction, it was determined that all of them were of the same clone. The previous use of quinolones and glycopeptides and an ICU stay were associated with the acquisition of infection or colonization with pan-drug-resistant A. baumannii. To control this outbreak, we implemented the following multicomponent intervention program: the performance of environmental decontamination of the ICUs involved, an environmental survey, a revision of cleaning protocols, active surveillance for colonization with pan-drug-resistant A. baumannii, educational programs for the staff, and the display of posters that illustrate contact isolation measures and antimicrobial use recommendations. We were not able to identify the common source for these cases of infection, but the adopted measures have proven to be effective at controlling the outbreak. es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Slack es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Medicina es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Microbiología es
dc.contributor.affiliation Instituto de Biomedicina de Sevilla (IBIS) es
dc.identifier.doi 10.1086/595977 es
idus.format.extent 7 es
dc.journaltitle Infection Control and Hospital Epidemiology es
dc.publication.volumen 30 es
dc.publication.issue 3 es
dc.publication.initialPage 257 es
dc.publication.endPage 263 es
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