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Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer

 

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Opened Access Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
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Author: Gasca, Jessica
Flores de Mera, María de la Luz
Giraldez Macias, Servando
Tortolero García, María Dolores
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2016
Published in: Oncotarget, 7 (33), 52751-52765.
Document type: Article
Abstract: FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by targeting MCL1 for ubiquitinat...
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Cite: Gasca, J., Flores, M.L., Giraldez Macias, S. y Tortolero García, M.D. (2016). Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer. Oncotarget, 7 (33), 52751-52765.
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URI: http://hdl.handle.net/11441/61384

DOI: 10.18632/oncotarget.10481

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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